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Anti-CDK5R1 Antibody

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产品名称: Anti-CDK5R1 Antibody
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简单介绍

Anti-CDK5R1 Antibody


Anti-CDK5R1 Antibody  的详细介绍
Name: Anti-CDK5R1 Antibody
See all CDK5R1 primary antibodies
Description: Rabbit polyclonal antibody to CDK5R1
Specificity: The antibody detects endogenous levels of total CDK5R1 protein.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from internal of human CDK5R1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Tissue Specificity: Brain and neuron specific.
Sequence Similarities: Belongs to the cyclin-dependent kinase 5 activator family.
Post-Translational Modification: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).
Cellular Location: Cell membrane.

In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Database Links:
  • Entrez Gene: 8851 Human
  • Entrez Gene: 12569 Mouse
  • Entrez Gene: 116671 Rat
  • Omim: 603460 Human
  • SwissProt: Q15078 Human
  • SwissProt: P61809 Mouse
  • SwissProt: P61810 Rat
  • Unigene: 500015 Human
  • Unigene: 142275 Mouse
  • Unigene: 474282 Mouse
  • Unigene: 11213 Rat
    		•
    Synonyms:
  • CD5R1_HUMAN Antibody
  • CDK5 activator 1 Antibody
  • CDK5P35 Antibody
  • CDK5R Antibody
  • CDK5R1 Antibody
  • Cyclin dependent kinase 5 regulatory subunit 1 Antibody
  • Cyclin-dependent kinase 5 activator 1 Antibody
  • Cyclin-dependent kinase 5 regulatory subunit 1 Antibody
  • NCK 5A Antibody
  • Neuronal CDK5 activator Antibody
  • p23 Antibody
  • p25 Antibody
  • p35 Antibody
  • Regulatory partner for CDK5 kinase Antibody
  • Tau protein kinase II 23 kDa subunit Antibody
  • TPKII regulatory subunit Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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