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Anti-CDK4 Antibody

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产品名称: Anti-CDK4 Antibody
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Anti-CDK4 Antibody


Anti-CDK4 Antibody  的详细介绍
Name: Anti-CDK4 Antibody
See all CDK4 primary antibodies
Description: Rabbit polyclonal antibody to CDK4
Specificity: The antibody detects endogenous levels of total CDK4 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Peptide sequence around aa.295~299(L-H-K-D-E)derived from Human CDK4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Involvement in Disease: Melanoma, cutaneous malignant 3: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Post-Translational Modification: Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
Cellular Location: Cytoplasm. Nucleus. Membrane.

Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Database Links:
  • Entrez Gene: 1019?Human
  • Omim: 123829?Human
  • SwissProt: P11802?Human
  • Unigene: 95577?Human
    		•
    Synonyms:
  • Cdk 4 Antibody
  • Cdk4 Antibody
  • CDK4 protein Antibody
  • CDK4_HUMAN Antibody
  • Cell division kinase 4 Antibody
  • Cell division protein kinase 4 Antibody
  • CMM 3 Antibody
  • CMM3 Antibody
  • Crk3 Antibody
  • Cyclin dependent kinase 4 Antibody
  • Cyclin-dependent kinase 4 Antibody
  • Melanoma cutaneous malignant 3 Antibody
  • MGC14458 Antibody
  • p34 cdk4 Antibody
  • PSK J3 Antibody
  • PSK-J3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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