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Anti-CDK12 Antibody

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产品名称: Anti-CDK12 Antibody
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Anti-CDK12 Antibody


Anti-CDK12 Antibody  的详细介绍
Name: Anti-CDK12 Antibody
See all CDK12 primary antibodies
Description: Rabbit polyclonal antibody to CDK12
Specificity: The antibody detects endogenous levels of total CDK12 protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human cyclin-dependent kinase 12
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 3.1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Tissue Specificity: Ubiquitously expressed.
Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Post-Translational Modification: Phosphorylation at Thr-893 increases kinase activity.
Cellular Location: Nucleus. Nucleus speckle.

Colocalized with nuclear speckles throughout interphase.
Database Links:
  • Entrez Gene: 51755?Human
  • Omim: 615514?Human
  • SwissProt: Q9NYV4?Human
  • Unigene: 416108?Human
    		•
    Synonyms:
  • arginine/serine-rich Antibody
  • Cdc2 related kinase arginine/serine rich Antibody
  • CDC2 related protein kinase 7 Antibody
  • Cdc2-related kinase Antibody
  • CDC2-related protein kinase 7 Antibody
  • Cdk12 Antibody
  • CDK12_HUMAN Antibody
  • Cell division cycle 2 related protein kinase 7 Antibody
  • Cell division cycle 2-related protein kinase 7 Antibody
  • Cell division protein kinase 12 Antibody
  • CRK7 Antibody
  • CRKR Antibody
  • CrkRS Antibody
  • Cyclin-dependent kinase 12 Antibody
  • EC 2.7.11.22 Antibody
  • hCDK12 Antibody
  • kiaa0904 Antibody
  • Pksc Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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