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Anti-CDCA1 Antibody

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产品名称: Anti-CDCA1 Antibody
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简单介绍

Anti-CDCA1 Antibody


Anti-CDCA1 Antibody  的详细介绍
Name: Anti-CDCA1 Antibody
See all CDCA1 primary antibodies
Description: Rabbit polyclonal antibody to CDCA1
Applications: WB, IF
Dilutions: Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200
Reactivity: Human
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule s in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Sequence Similarities: Belongs to the NUF2 family.
Post-Translational Modification: Can be phosphorylated by AURKA and AURKB.
Cellular Location: Nucleus. Chromosome > Centromere > Kinetochore.

Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
Database Links:
  • Entrez Gene: 83540 Human
  • Omim: 611772 Human
  • SwissProt: Q9BZD4 Human
  • Unigene: 651950 Human
    		•
    Synonyms:
  • Cancer/testis antigen 106 Antibody
  • CDCA 1 Antibody
  • CDCA1 Antibody
  • Cell division cycle associated 1 Antibody
  • Cell division cycle associated protein 1 Antibody
  • Cell division cycle-associated protein 1 Antibody
  • CT106 Antibody
  • hNuf 2 Antibody
  • hNuf2 Antibody
  • hNuf2R Antibody
  • hsNuf2 Antibody
  • Kinetochore protein Nuf2 Antibody
  • Nuf 2 Antibody
  • Nuf2 Antibody
  • NUF2 NDC80 kinetochore complex component Antibody
  • NUF2 NDC80 kinetochore complex component homolog Antibody
  • NUF2, S. cerevisiae, homolog of Antibody
  • NUF2R Antibody
  • NUF2_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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