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Anti-Cdc25C (phospho-S216) Antibody

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产品名称: Anti-Cdc25C (phospho-S216) Antibody
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Anti-Cdc25C (phospho-S216) Antibody


Anti-Cdc25C (phospho-S216) Antibody  的详细介绍
Name: Anti-Cdc25C (phospho-S216) Antibody
See all Cdc25C primary antibodies
Description: Rabbit polyclonal antibody to Cdc25C (phospho-S216)
Specificity: p-CDC25C (S216) pAb detects endogenous levels of CDC25C protein only when phosphorylated at Ser216.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human Cdc25C around the phosphorylation site of Serine 216.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 53 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
Sequence Similarities: Belongs to the MPI phosphatase family.
Post-Translational Modification: Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 995?Human
  • Entrez Gene: 12532?Mouse
  • Entrez Gene: 307511?Rat
  • Omim: 157680?Human
  • SwissProt: P30307?Human
  • SwissProt: P48967?Mouse
  • Unigene: 656?Human
  • Unigene: 286602?Mouse
  • Unigene: 162298?Rat
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    Synonyms:
  • CDC 25 Antibody
  • Cdc 25C Antibody
  • CDC25 Antibody
  • Cdc25C Antibody
  • Cell division cycle 25 homolog C Antibody
  • Cell division cycle 25C Antibody
  • Cell division cycle 25C protein Antibody
  • Dual specificity phosphatase Cdc25C Antibody
  • M phase inducer phosphatase 3 Antibody
  • M-phase inducer phosphatase 3 Antibody
  • Mitosis inducer CDC25 Antibody
  • MPIP3 Antibody
  • MPIP3_HUMAN Antibody
  • Phosphotyrosine phosphatase Antibody
  • PPP1R60 Antibody
  • protein phosphatase 1, regulatory subunit 60 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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