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Anti-CDC25B Antibody

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产品名称: Anti-CDC25B Antibody
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Anti-CDC25B Antibody


Anti-CDC25B Antibody  的详细介绍
Name: Anti-CDC25B Antibody
See all CDC25B primary antibodies
Description: Rabbit polyclonal antibody to CDC25B
Specificity: The antibody detects endogenous levels of total CDC25B protein.
Applications: WB, IHC
Dilutions: Western blotting: 1:200-1:1000 Immunohistochemistry: 1:50-1:200
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human cell division cycle 25B
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Sequence Similarities: Belongs to the MPI phosphatase family.
Post-Translational Modification: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle pole.
Database Links:
  • Entrez Gene: 994?Human
  • Entrez Gene: 12531?Mouse
  • Omim: 116949?Human
  • SwissProt: P30305?Human
  • SwissProt: P30306?Mouse
  • Unigene: 153752?Human
  • Unigene: 38444?Mouse
    		•
    Synonyms:
  • AI604853 Antibody
  • Cdc 25B Antibody
  • Cdc25B Antibody
  • CDC25HU2 Antibody
  • Cdc25m2 Antibody
  • Cell division cycle 25 homolog B Antibody
  • Cell division cycle 25B Antibody
  • Cell division cycle 25B isoform 1 Antibody
  • Cell division cycle 25B isoform 2 Antibody
  • Cell division cycle 25B isoform 3 Antibody
  • Cell division cycle 25B isoform 4 Antibody
  • Cell division cycle 25B isoform 5 Antibody
  • Dual specificity phosphatase Cdc25B Antibody
  • EC 3.1.3.48 Antibody
  • M phase inducer phosphatase 2 Antibody
  • M-phase inducer phosphatase 2 Antibody
  • MPIP2_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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