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Anti-Cdc25A (K120) Antibody

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产品名称: Anti-Cdc25A (K120) Antibody
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Anti-Cdc25A (K120) Antibody


Anti-Cdc25A (K120) Antibody  的详细介绍
Name: Anti-Cdc25A (K120) Antibody
See all Cdc25A primary antibodies
Description: Rabbit polyclonal antibody to Cdc25A (K120)
Specificity: Cdc25A (K120) pAb detects endogenous levels of Cdc25A protein.
Applications: IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 280-340 of Human Cdc25A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 59, 70 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Sequence Similarities: Belongs to the MPI phosphatase family.
Post-Translational Modification: Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates s for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
Database Links:
  • Entrez Gene: 993?Human
  • Entrez Gene: 12530?Mouse
  • Entrez Gene: 171102?Rat
  • Omim: 116947?Human
  • SwissProt: P30304?Human
  • SwissProt: P48964?Mouse
  • SwissProt: P48965?Rat
  • Unigene: 437705?Human
  • Unigene: 307103?Mouse
  • Unigene: 11390?Rat
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    Synonyms:
  • Cdc 25a Antibody
  • Cdc25A Antibody
  • CDC25A2 Antibody
  • CDC25A2 CAG isoform Antibody
  • Cell division cycle 25 homolog A (S. pombe) Antibody
  • Cell division cycle 25A Antibody
  • Cell division cycle 25A isoform a Antibody
  • Cell division cycle 25A isoform b Antibody
  • D9Ertd393e Antibody
  • Dual specificity phosphatase Cdc25A Antibody
  • M phase inducer phosphatase 1 Antibody
  • M-phase inducer phosphatase 1 Antibody
  • MGC115549 Antibody
  • MPIP1_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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