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Anti-CDC25A (Ab-178) Antibody

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产品名称: Anti-CDC25A (Ab-178) Antibody
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Anti-CDC25A (Ab-178) Antibody


Anti-CDC25A (Ab-178) Antibody  的详细介绍
Name: Anti-CDC25A (Ab-178) Antibody
See all CDC25A primary antibodies
Description: Rabbit polyclonal antibody to CDC25A (Ab-178)
Specificity: The antibody detects endogenous levels of total CDC25A protein.
Applications: WB
Reactivity: Human
Immunogen: Synthesized non-phosphopeptide derived from human CDC25A around the phosphorylation site of serine 178 (Q-N-S(p)-A-P).
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Sequence Similarities: Belongs to the MPI phosphatase family.
Post-Translational Modification: Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates s for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
Database Links:
  • Entrez Gene: 993 Human
  • Omim: 116947 Human
  • SwissProt: P30304 Human
  • Unigene: 437705 Human
    		•
    Synonyms:
  • Cdc 25a Antibody
  • Cdc25A Antibody
  • CDC25A2 Antibody
  • CDC25A2 CAG isoform Antibody
  • Cell division cycle 25 homolog A (S. pombe) Antibody
  • Cell division cycle 25A Antibody
  • Cell division cycle 25A isoform a Antibody
  • Cell division cycle 25A isoform b Antibody
  • D9Ertd393e Antibody
  • Dual specificity phosphatase Cdc25A Antibody
  • M phase inducer phosphatase 1 Antibody
  • M-phase inducer phosphatase 1 Antibody
  • MGC115549 Antibody
  • MPIP1_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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