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Anti-CDC16 Antibody

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产品名称: Anti-CDC16 Antibody
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Anti-CDC16 Antibody


Anti-CDC16 Antibody  的详细介绍
Name: Anti-CDC16 Antibody
See all CDC16 primary antibodies
Description: Rabbit polyclonal antibody to CDC16
Specificity: The antibody detects endogenous levels of total CDC16 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues near the N terminal of human cell division cycle 16
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.9mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Sequence Similarities: Belongs to the APC6/CDC16 family.
Post-Translational Modification: Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle.

Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
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