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Anti-Cdc16 (K556) Antibody

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产品名称: Anti-Cdc16 (K556) Antibody
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Anti-Cdc16 (K556) Antibody


Anti-Cdc16 (K556) Antibody  的详细介绍
Name: Anti-Cdc16 (K556) Antibody
See all Cdc16 primary antibodies
Description: Rabbit polyclonal antibody to Cdc16 (K556)
Specificity: Cdc16 (K556) pAb detects endogenous levels of Cdc16 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 530-580 of Human Cdc16.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 72 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Sequence Similarities: Belongs to the APC6/CDC16 family.
Post-Translational Modification: Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle.

Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
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