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Anti-CD86 Antibody

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产品名称: Anti-CD86 Antibody
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简单介绍

Anti-CD86 Antibody


Anti-CD86 Antibody  的详细介绍
Name: Anti-CD86 Antibody
See all CD86 primary antibodies
Description: Mouse monoclonal (BU63) antibody to CD86 (APC).
Specificity: The antibody BU63 reacts with CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Applications: FC, IP, WB, IHC-Fr, FUNC
Reactivity: Human
Immunogen: B-lymphoblastoid cell line ARH 77.
Host: Mouse
Clonality: Monoclonal
Clone: BU63
Isotype: IgG1
Conjugate: APC
Purification: Size exclusion chromatography.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Tissue Specificity: Expressed by activated B-lymphocytes and monocytes.
Post-Translational Modification: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 942?Human
  • Omim: 601020?Human
  • SwissProt: P42081?Human
  • Unigene: 171182?Human
    		•
    Synonyms:
  • Activation B7-2 antigen Antibody
  • Activation B7-2 antigen 3 Antibody
  • B-lymphocyte activation antigen B7-2 Antibody
  • B-lymphocyte activation antigen B7-2 2 Antibody
  • B7 Antibody
  • B7 2 Antibody
  • B7-2 Antibody
  • B7.2 Antibody
  • B70 Antibody
  • B72 antigen Antibody
  • BU63 Antibody
  • CD28 antigen ligand 2 Antibody
  • CD28 antigen ligand 2 2 Antibody
  • Cd28l2 Antibody
  • CD28LG2 Antibody
  • CD86 Antibody
  • CD86 antigen Antibody
  • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) Antibody
  • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2 Antibody
  • CD86 molecule Antibody
  • CD86_HUMAN Antibody
  • CLS1 Antibody
  • CTLA-4 counter-receptor B7.2 Antibody
  • CTLA-4 counter-receptor B7.2 2, 3 Antibody
  • Early T-cell costimulatory molecule 1 Antibody
  • ETC-1 Antibody
  • FUN 1 Antibody
  • FUN-1 Antibody
  • LAB72 Antibody
  • Ly-58 Antibody
  • Ly58 Antibody
  • MB7 Antibody
  • MB7-2 Antibody
  • Membrane glycoprotein Antibody
  • MGC34413 Antibody
  • T-lymphocyte activation antigen CD86 Antibody
  • TS/A-2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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