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Anti-CD79B Antibody

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产品名称: Anti-CD79B Antibody
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简单介绍

Anti-CD79B Antibody


Anti-CD79B Antibody  的详细介绍
Name: Anti-CD79B Antibody
See all CD79B primary antibodies
Description: Rabbit polyclonal antibody to CD79B.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CD79B.
Protein Length: 229
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Tissue Specificity: B-cells.
Involvement in Disease: Agammaglobulinemia 6, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Post-Translational Modification: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Cellular Location: Cell membrane.

Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Database Links:
  • Entrez Gene: 974?Human
  • Entrez Gene: 15985?Mouse
  • Entrez Gene: 171055?Rat
  • Omim: 147245?Human
  • SwissProt: P40259?Human
  • SwissProt: P15530?Mouse
  • Unigene: 89575?Human
  • Unigene: 2987?Mouse
  • Unigene: 62607?Rat
    		•
    Synonyms:
  • AGM6 Antibody
  • B cell antigen receptor complex associated protein beta chain Antibody
  • B cell specific glycoprotein B29 Antibody
  • B-cell antigen receptor complex-associated protein beta chain Antibody
  • B-cell-specific glycoprotein B29 Antibody
  • B29 Antibody
  • B29/Ig-beta/CD79b Antibody
  • CD 79b Antibody
  • CD79b Antibody
  • CD79b antigen Antibody
  • CD79b antigen (immunoglobulin associated beta) Antibody
  • CD79b molecule Antibody
  • CD79b molecule immunoglobulin associated beta Antibody
  • CD79b protein Antibody
  • CD79B_HUMAN Antibody
  • Ig beta Antibody
  • Ig-beta Antibody
  • IGB Antibody
  • Igbeta Antibody
  • Immunoglobulin associated B29 Antibody
  • Immunoglobulin associated B29 protein Antibody
  • Immunoglobulin associated beta Antibody
  • Immunoglobulin associated protein Antibody
  • Immunoglobulin-associated B29 protein Antibody
  • MGC108607 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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