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Anti-CD79a Antibody

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产品名称: Anti-CD79a Antibody
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Anti-CD79a Antibody


Anti-CD79a Antibody  的详细介绍
Name: Anti-CD79a Antibody
See all CD79a primary antibodies
Description: Mouse monoclonal (HM47) antibody to CD79a (PE).
Specificity: The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
Applications: FC, IP, WB, IHC-P
Reactivity: Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Dog, Horse, Guinea Pig, Rabbit, Chicken
Immunogen: Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a.
Host: Mouse
Clonality: Monoclonal
Clone: HM47
Isotype: IgG1
Conjugate: PE
Purification: Size exclusion chromatography.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Tissue Specificity: B-cells.
Post-Translational Modification: Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
Cellular Location: Cell membrane.

Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Database Links:
  • Entrez Gene: 281674?Cow
  • Entrez Gene: 484483?Dog
  • Entrez Gene: 973?Human
  • Entrez Gene: 12518?Mouse
  • Entrez Gene: 681236?Rat
  • Omim: 112205?Human
  • SwissProt: P40293?Cow
  • SwissProt: P0CAN6?Dog
  • SwissProt: P11912?Human
  • SwissProt: P11911?Mouse
  • Unigene: 631567?Human
  • Unigene: 1355?Mouse
    		•
    Synonyms:
  • B lymphocyte-specific MB1 protein Antibody
  • B-cell antigen receptor complex-associated protein alpha chain Antibody
  • CD 79a Antibody
  • CD79a Antibody
  • CD79A antigen Antibody
  • CD79a antigen (immunoglobulin-associated alpha) Antibody
  • CD79a molecule, immunoglobulin-associated alpha Antibody
  • CD79A_HUMAN Antibody
  • Ig alpha Antibody
  • Ig-alpha Antibody
  • IGA Antibody
  • IgM-alpha Antibody
  • Immunoglobulin-associated alpha Antibody
  • Ly54 Antibody
  • MB-1 membrane glycoprotein Antibody
  • MB1 Antibody
  • Membrane-bound immunoglobulin-associated protein Antibody
  • Surface IgM-associated protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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