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Anti-CD63 (8H2) Antibody

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产品名称: Anti-CD63 (8H2) Antibody
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Anti-CD63 (8H2) Antibody


Anti-CD63 (8H2) Antibody  的详细介绍
Name: Anti-CD63 (8H2) Antibody
See all CD63 primary antibodies
Description: Mouse monoclonal antibody to CD63 (8H2)
Specificity: CD63 (8H2) mouse monoclonal antibody detects endogenous levels of CD63 protein
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human CD63.
Host: Mouse
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 25 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Tissue Specificity: Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence Similarities: Belongs to the tetraspanin (TM4SF) family.
Post-Translational Modification: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Cellular Location: Cell membrane. Lysosome membrane. Late endosome membrane. Endosome > Multivesicular body. Melanosome. Secreted > Exosome. Cell surface.

Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Database Links:
  • Entrez Gene: 967 Human
  • Entrez Gene: 12512 Mouse
  • Entrez Gene: 29186 Rat
  • Omim: 155740 Human
  • SwissProt: P08962 Human
  • SwissProt: P41731 Mouse
  • SwissProt: P28648 Rat
  • Unigene: 445570 Human
  • Unigene: 371552 Mouse
  • Unigene: 416079 Mouse
  • Unigene: 11068 Rat
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    Synonyms:
  • Lysosomal associated membrane protein 3 Antibody
  • CD 63 Antibody
  • CD63 Antibody
  • CD63 antigen Antibody
  • CD63 antigen (melanoma 1 antigen) Antibody
  • CD63 antigen melanoma 1 antigen Antibody
  • CD63 molecule Antibody
  • CD63_HUMAN Antibody
  • gp55 Antibody
  • Granulophysin Antibody
  • LAMP 3 Antibody
  • LAMP-3 Antibody
  • LAMP3 Antibody
  • LIMP Antibody
  • Lysosomal-associated membrane protein 3 Antibody
  • Lysosome associated membrane glycoprotein 3 Antibody
  • Mast cell antigen AD1 Antibody
  • ME491 Antibody
  • Melanoma 1 antigen Antibody
  • Melanoma associated antigen ME491 Antibody
  • Melanoma associated antigen MLA1 Antibody
  • Melanoma-associated antigen ME491 Antibody
  • MGC72893 Antibody
  • MLA 1 Antibody
  • MLA1 Antibody
  • NGA Antibody
  • Ocular melanoma associated antigen Antibody
  • Ocular melanoma-associated antigen Antibody
  • OMA81H Antibody
  • PTLGP40 Antibody
  • Tetraspanin 30 Antibody
  • Tetraspanin-30 Antibody
  • Tspan 30 Antibody
  • Tspan-30 Antibody
  • TSPAN30 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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