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Anti-CD62P Antibody

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产品名称: Anti-CD62P Antibody
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简单介绍

Anti-CD62P Antibody


Anti-CD62P Antibody  的详细介绍
Name: Anti-CD62P Antibody
See all CD62P primary antibodies
Description: Mouse monoclonal (AK4) antibody to CD62P.
Specificity: The antibody HI62P recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Applications: FC, IP, WB, ICC, FUNC
Reactivity: Human, Non-Human Primates
Immunogen: Human platelets.
Host: Mouse
Clonality: Monoclonal
Clone: AK4
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 µm filter sterilised). Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
Storage: Store at 2-8°C.
Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Tissue Specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Involvement in Disease: Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequence Similarities: Belongs to the selectin/LECAM family.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 6403 Human
  • Omim: 173610 Human
  • SwissProt: P16109 Human
  • Unigene: 73800 Human
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    Synonyms:
  • Antigen CD62 Antibody
  • CD62 Antibody
  • CD62 antigen like family member P Antibody
  • CD62 antigen-like family member P Antibody
  • CD62P Antibody
  • FLJ45155 Antibody
  • GMP 140 Antibody
  • GMP-140 Antibody
  • GMP140 Antibody
  • GMRP Antibody
  • Granule membrane protein 140 Antibody
  • Granule membrane protein 140kDa Antibody
  • Granulocyte membrane protein Antibody
  • GRMP Antibody
  • LECAM 3 Antibody
  • LECAM3 Antibody
  • Leukocyte endothelial cell adhesion molecule 3 Antibody
  • Leukocyte-endothelial cell adhesion molecule 3 Antibody
  • LYAM3_HUMAN Antibody
  • P selectin Antibody
  • P-selectin Antibody
  • PADGEM Antibody
  • Platelet activation dependent granule external membrane protein Antibody
  • Platelet activation dependent granule-external membrane protein Antibody
  • Platelet alpha granule membrane protein Antibody
  • PSEL Antibody
  • Selectin P Antibody
  • Selectin P (granule membrane protein 140kDa antigen CD62) Antibody
  • Selectin P (granule membrane protein 140kDa, antigen CD62) Antibody
  • SELP Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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