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Anti-CD46 Antibody

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产品名称: Anti-CD46 Antibody
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简单介绍

Anti-CD46 Antibody


Anti-CD46 Antibody  的详细介绍
Name: Anti-CD46 Antibody
See all CD46 primary antibodies
Description: Rabbit polyclonal antibody to CD46.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human CD46.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Tissue Specificity: Expressed by all cells except erythrocytes.
Involvement in Disease: Hemolytic uremic syndrome atypical 2: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Post-Translational Modification: N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.
Cellular Location: Cytoplasmic vesicle > Secretory vesicle > Acrosome inner membrane.

Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
Database Links:
  • Entrez Gene: 4179?Human
  • Entrez Gene: 17221?Mouse
  • Omim: 120920?Human
  • SwissProt: P15529?Human
  • SwissProt: O88174?Mouse
  • Unigene: 510402?Human
  • Unigene: 12884?Mouse
  • Synonyms:
  • AHUS2 Antibody
  • Antigen defined by monoclonal Antibody
  • Antigen identified by monoclonal Antibody
  • CD46 Antibody
  • CD46 antigen Antibody
  • CD46 antigen complement regulatory protein Antibody
  • CD46 molecule Antibody
  • CD46 molecule complement regulatory protein Antibody
  • Complement membrane cofactor protein Antibody
  • MCP Antibody
  • MCP_HUMAN Antibody
  • Measles virus receptor Antibody
  • Membrane cofactor protein Antibody
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) Antibody
  • MGC26544 Antibody
  • MIC10 Antibody
  • TLX Antibody
  • TRA2.10 Antibody
  • Trophoblast leucocyte common antigen Antibody
  • Trophoblast leukocyte common antigen Antibody
  • Trophoblast lymphocyte cross reactive antigen Antibody
  • Information: Target information shown above is from the UniProt Consortium.
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