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Antibodies
Anti-CD46 Antibody
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产品名称:
Anti-CD46 Antibody
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简单介绍
Anti-CD46
Antibody
Anti-CD46 Antibody
的详细介绍
Overview
Name:
Anti-CD46
Antibody
See all CD46 primary antibodies
Description:
Rabbit polyclonal antibody to CD46.
Applications:
WB, IHC, IF
Dilutions:
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity:
Human, Mouse
Immunogen:
Recombinant protein of human CD46.
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Affinity purification.
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
Tissue Specificity:
Expressed by all cells except erythrocytes.
Involvement in Disease:
Hemolytic uremic syndrome atypical 2: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Post-Translational Modification:
N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.
Cellular Location:
Cytoplasmic vesicle > Secretory vesicle > Acrosome inner membrane.
Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
Database Links:
Entrez Gene: 4179?Human
Entrez Gene: 17221?Mouse
Omim: 120920?Human
SwissProt: P15529?Human
SwissProt: O88174?Mouse
Unigene: 510402?Human
Unigene: 12884?Mouse
Synonyms:
AHUS2 Antibody
Antigen defined by monoclonal Antibody
Antigen identified by monoclonal Antibody
CD46 Antibody
CD46 antigen Antibody
CD46 antigen complement regulatory protein Antibody
CD46 molecule Antibody
CD46 molecule complement regulatory protein Antibody
Complement membrane cofactor protein Antibody
MCP Antibody
MCP_HUMAN Antibody
Measles virus receptor Antibody
Membrane cofactor protein Antibody
membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) Antibody
MGC26544 Antibody
MIC10 Antibody
TLX Antibody
TRA2.10 Antibody
Trophoblast leucocyte common antigen Antibody
Trophoblast leukocyte common antigen Antibody
Trophoblast lymphocyte cross reactive antigen Antibody
Information:
Target information shown above is from the UniProt Consortium.
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