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Anti-CD44 Antibody

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产品名称: Anti-CD44 Antibody
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简单介绍

Anti-CD44 Antibody


Anti-CD44 Antibody  的详细介绍
Name: Anti-CD44 Antibody
See all CD44 primary antibodies
Description: Mouse monoclonal (MEM-263) antibody to CD44 (APC).
Specificity: The antibody MEM-263 reacts with extracellular (N-terminal) domain of standard CD44 (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes.
Applications: FC, IP, WB, IHC-P
Reactivity: Human, Porcine, Dog
Immunogen: COS-7 (African Green Monkey) cells.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-263
Isotype: IgG1
Conjugate: APC
Purification: Size exclusion chromatography.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
Tissue Specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
Post-Translational Modification: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
Cellular Location: Cell membrane.

Colocalizes with actin in membrane protrusions at wounding edges.
Database Links:
  • Entrez Gene: 403939?Dog
  • Entrez Gene: 960?Human
  • Entrez Gene: 100525150?Pig
  • Omim: 107269?Human
  • SwissProt: Q28284?Dog
  • SwissProt: P16070?Human
  • Unigene: 502328?Human
    		•
    Synonyms:
  • LHR Antibody
  • BA-1 Antibody
  • CD 44 Antibody
  • CD44 Antibody
  • CD44 antigen Antibody
  • CD44 molecule Antibody
  • CD44 molecule (Indian blood group) Antibody
  • CD44_HUMAN Antibody
  • CDw44 Antibody
  • Cell surface glycoprotein CD44 Antibody
  • chondroitin sulfate proteoglycan 8 Antibody
  • CSPG8 Antibody
  • ECMR-III Antibody
  • Epican Antibody
  • Extracellular matrix receptor III Antibody
  • GP90 lymphocyte homing/adhesion receptor Antibody
  • HCELL Antibody
  • hematopoietic cell E- and L-selectin ligand Antibody
  • Heparan sulfate proteoglycan Antibody
  • Hermes antigen Antibody
  • homing function and Indian blood group system Antibody
  • HSA Antibody
  • HUTCH-I Antibody
  • HUTCH1 Antibody
  • Hyaluronate receptor Antibody
  • IN Antibody
  • INLU-related p80 Glycoprotein Antibody
  • MC56 Antibody
  • MDU2 Antibody
  • MDU3 Antibody
  • MGC10468 Antibody
  • MIC4 Antibody
  • MUTCH1 Antibody
  • PGP-1 Antibody
  • PGP-I Antibody
  • PGP1 Antibody
  • Phagocytic glycoprotein 1 Antibody
  • Phagocytic glycoprotein I Antibody
  • Soluble CD44 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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