产品资料

Anti-CD41 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-CD41 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-CD41 Antibody


Anti-CD41 Antibody  的详细介绍
Name: Anti-CD41 Antibody
See all CD41 primary antibodies
Description: Mouse monoclonal (MEM-06) antibody to CD41 (Biotin).
Specificity: The antibody MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Applications: FC
Reactivity: Human
Immunogen: Leukocytes from a patient suffering from a LGL Type leukemia.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-06
Isotype: IgG1
Conjugate: Biotin
Concentration: 1 mg/ml
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Tissue Specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Involvement in Disease: Glanzmann thrombasthenia: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.

Bleeding disorder, platelet-type 16: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
Sequence Similarities: Belongs to the integrin alpha chain family.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 3674 Human
  • Omim: 607759 Human
  • SwissProt: P08514 Human
  • Unigene: 411312 Human
    		•
    Synonyms:
  • antigen CD41 Antibody
  • BDPLT16 Antibody
  • BDPLT2 Antibody
  • CD41 Antibody
  • CD41B Antibody
  • form 2 Antibody
  • GP2B Antibody
  • GPalpha IIb Antibody
  • GPIIb Antibody
  • GT Antibody
  • GTA Antibody
  • HPA3 Antibody
  • Integrin alpha 2b Antibody
  • Integrin alpha IIb Antibody
  • Integrin alpha-IIb light chain Antibody
  • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Antibody
  • ITA2B_HUMAN Antibody
  • Itga2b Antibody
  • ITGAB Antibody
  • platelet fibrinogen receptor, alpha subunit Antibody
  • platelet glycoprotein IIb of IIb/IIIa complex Antibody
  • Platelet membrane glycoprotein IIb Antibody
  • platelet specific antigen BAK Antibody
  • PPP1R93 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号