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Anti-CD305 Antibody

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产品名称: Anti-CD305 Antibody
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Anti-CD305 Antibody


Anti-CD305 Antibody  的详细介绍
Name: Anti-CD305 Antibody
See all CD305 primary antibodies
Description: Rabbit polyclonal antibody to CD305
Specificity: CD305 Polyclonal Antibody detects endogenous levels of CD305 protein.
Applications: WB, ELISA
Reactivity: Human
Immunogen: Synthesized peptide derived from the Internal region of human CD305.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20˚C / 1 year
Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Tissue Specificity: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.
Post-Translational Modification: Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 3903 Human
  • Omim: 602992 Human
  • SwissProt: Q6GTX8 Human
  • Unigene: 572535 Human
    		•
    Synonyms:
  • 5133400O11Rik Antibody
  • CD305 Antibody
  • D7Bwg0421e Antibody
  • hLAIR1 Antibody
  • LAIR 1 Antibody
  • LAIR-1 Antibody
  • LAIR1 Antibody
  • LAIR1 protein Antibody
  • LAIR1_HUMAN Antibody
  • Leukocyte associated Ig like receptor 1 Antibody
  • Leukocyte associated immunoglobulin like receptor 1 Antibody
  • Leukocyte-associated immunoglobulin-like receptor 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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