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Anti-CD3-ε Antibody

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产品名称: Anti-CD3-ε Antibody
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Anti-CD3-ε Antibody


Anti-CD3-ε Antibody  的详细介绍
Name: Anti-CD3-ε Antibody
See all CD3-ε primary antibodies
Description: Rabbit polyclonal antibody to CD3-ε
Specificity: CD3-ε pAb detects endogenous levels of CD3-ε protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CD3-ε.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 21 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).
Involvement in Disease: Immunodeficiency 18: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18.
Cellular Location: Cell membrane.
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