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Anti-CD267 Antibody

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产品名称: Anti-CD267 Antibody
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Anti-CD267 Antibody


Anti-CD267 Antibody  的详细介绍
Name: Anti-CD267 Antibody
See all CD267 primary antibodies
Description: Rabbit polyclonal antibody to CD267
Specificity: CD267 Polyclonal Antibody detects endogenous levels of CD267 protein.
Applications: WB, ELISA
Reactivity: Human
Immunogen: Synthesized peptide derived from the Internal region of human CD267.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20˚C / 1 year
Function: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Tissue Specificity: Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.
Involvement in Disease: Immunodeficiency, common variable, 2: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Immunoglobulin A deficiency 2: Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 23495 Human
  • Omim: 604907 Human
  • SwissProt: O14836 Human
  • Unigene: 158341 Human
    		•
    Synonyms:
  • CD 267 Antibody
  • CD267 Antibody
  • CD267 antigen Antibody
  • CVID Antibody
  • CVID2 Antibody
  • FLJ39942 Antibody
  • MGC133214 Antibody
  • MGC39952 Antibody
  • OTTHUMP00000065442 Antibody
  • TACI Antibody
  • TNFRSF 13B Antibody
  • TNFRSF 14B Antibody
  • TNFRSF13B Antibody
  • TNFRSF13B protein Antibody
  • TNFRSF14B Antibody
  • TR13B_HUMAN Antibody
  • Transmembrane activator and CAML interactor Antibody
  • Tumor necrosis factor receptor 13B Antibody
  • Tumor necrosis factor receptor superfamily member 13B Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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