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Anti-CD235a Antibody

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产品名称: Anti-CD235a Antibody
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Anti-CD235a Antibody


Anti-CD235a Antibody  的详细介绍
Name: Anti-CD235a Antibody
See all Glycophorin A primary antibodies
Description: Mouse monoclonal (JC159) antibody to CD235a.
Specificity: The mouse monoclonal antibody JC159 recognizes an epitope between amino acids 27 and 40 of the extracellular portion of CD235a (glycophorin A), a sialoglycoprotein expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL. The antibody does not react with glycophorin B.
Applications: FC, IHC-P, IHC-Fr
Reactivity: Human, Rat
Immunogen: Membrane preparation from splenic hairy cell leukemia.
Host: Mouse
Clonality: Monoclonal
Clone: JC159
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Sequence Similarities: Belongs to the glycophorin A family.
Post-Translational Modification: The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
Cellular Location: Cell membrane.

Appears to be colocalized with SLC4A1.
Database Links:
  • Entrez Gene: 2993?Human
  • Entrez Gene: 688972?Rat
  • Omim: 111300?Human
  • SwissProt: P02724?Human
  • Unigene: 434973?Human
    		•
    Synonyms:
  • AI853584 Antibody
  • Blood group--MN locus Antibody
  • CD235a Antibody
  • CD_antigen=CD235a Antibody
  • GLPA_HUMAN Antibody
  • Glycophorin A Antibody
  • Glycophorin A (MNS blood group) Antibody
  • Glycophorin A, included Antibody
  • Glycophorin-A Antibody
  • GlycophorinA Antibody
  • GPA Antibody
  • GPErik Antibody
  • GpMiIII Antibody
  • GPSAT Antibody
  • GYPA Antibody
  • GYPA, included Antibody
  • HGpMiIII Antibody
  • HGpMiV Antibody
  • HGpMiX Antibody
  • HGpMiXI Antibody
  • HGpSta(C) Antibody
  • MN Antibody
  • MN sialoglycoprotein Antibody
  • MNS Antibody
  • PAS-2 Antibody
  • PAS2 Antibody
  • Sialoglycoprotein alpha Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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