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Anti-CD222 Antibody

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产品名称: Anti-CD222 Antibody
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Anti-CD222 Antibody


Anti-CD222 Antibody  的详细介绍
Name: Anti-CD222 Antibody
See all M6PR (cation independent) primary antibodies
Description: Mouse monoclonal (MEM-238) antibody to CD222 (PE).
Specificity: The antibody MEM-238 recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
Applications: FC, WB
Reactivity: Human, Non-Human Primates
Immunogen: Recombinant Vaccinia virus encoding CD222.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-238
Isotype: IgG1
Conjugate: PE
Purification: Size exclusion chromatography.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Sequence Similarities: Belongs to the MRL1/IGF2R family.
Cellular Location: Lysosome membrane.

Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Database Links:
  • Entrez Gene: 3482 Human
  • Omim: 147280 Human
  • SwissProt: P11717 Human
  • Unigene: 487062 Human
  • Unigene: 673278 Human
    		•
    Synonyms:
  • 300 kDa mannose 6 phosphate receptor Antibody
  • 300 kDa mannose 6-phosphate receptor Antibody
  • Cation independent mannose 6 phosphate receptor Antibody
  • Cation-independent mannose-6-phosphate receptor Antibody
  • CD222 Antibody
  • CD222 antigen Antibody
  • CI Man 6 P receptor Antibody
  • CI Man-6-P receptor Antibody
  • CI MPR Antibody
  • CI-M6PR Antibody
  • CI-MPR Antibody
  • CIMPR Antibody
  • IGF 2 receptor Antibody
  • IGF 2R Antibody
  • IGF II receptor Antibody
  • IGF-II receptor Antibody
  • IGF2 receptor Antibody
  • Igf2r Antibody
  • Insulin like growth factor 2 receptor Antibody
  • Insulin like growth factor II receptor Antibody
  • Insulin-like growth factor 2 receptor Antibody
  • Insulin-like growth factor II receptor Antibody
  • M6P R Antibody
  • M6P/IGF2 receptor Antibody
  • M6P/IGF2R Antibody
  • M6PR Antibody
  • M6PR (cation independent) Antibody
  • mannose 6 phosphate receptor Antibody
  • mannose 6 phosphate receptor, cation independent Antibody
  • MPR 300 Antibody
  • MPR300 Antibody
  • MPRI Antibody
  • MPRI_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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