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Anti-CD11b Antibody

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产品名称: Anti-CD11b Antibody
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简单介绍

Anti-CD11b Antibody


Anti-CD11b Antibody  的详细介绍
Name: Anti-CD11b Antibody
See all CD11b primary antibodies
Description: Mouse monoclonal (MEM-174) antibody to CD11b (PE).
Specificity: The antibody MEM-174 recognizes CD11b antigen (Mac-1 alpha), a 165-170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
Applications: FC, IP
Reactivity: Human
Immunogen: Human granulocytes.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-174
Isotype: IgG2a
Conjugate: PE
Purification: Size exclusion chromatography.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage: Store in the dark at 2-8°C. Avoid prolonged exposure to light.
Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue Specificity: Predominantly expressed in monocytes and granulocytes.
Involvement in Disease: Systemic lupus erythematosus 6: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Sequence Similarities: Belongs to the integrin alpha chain family.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 3684 Human
  • Omim: 120980 Human
  • SwissProt: P11215 Human
  • Unigene: 172631 Human
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    Synonyms:
  • antigen CD11b (p170) Antibody
  • Antigen CD11b p170 Antibody
  • CD11 antigen like family member B Antibody
  • CD11 antigen-like family member B Antibody
  • CD11b Antibody
  • CD11b/CD18 Antibody
  • CD49d Antibody
  • Cell surface glycoprotein MAC-1 subunit alpha Antibody
  • Complement component 3 receptor 3 subunit Antibody
  • Complement Component Receptor 3 Alpha Antibody
  • Complement receptor type 3, alpha subunit Antibody
  • CR 3 alpha chain Antibody
  • CR 3 alpha chain (CR3A) Antibody
  • CR-3 alpha chain Antibody
  • CR3 Antibody
  • CR3A Antibody
  • F730045J24Rik Antibody
  • Integrin Alpha M Antibody
  • Integrin alpha M chain Antibody
  • Integrin alpha-M Antibody
  • Integrin beta 2 alpha subunit Antibody
  • Integrin subunit alpha M Antibody
  • integrin, alpha M (complement component 3 receptor 3 subunit) Antibody
  • ITAM_HUMAN Antibody
  • ITGAM Antibody
  • Leukocyte adhesion receptor MO1 Antibody
  • Ly-40 Antibody
  • MAC 1 Antibody
  • Mac-1a Antibody
  • MAC1 Antibody
  • Mac1, alpha subunit Antibody
  • MAC1A Antibody
  • Macrophage antigen alpha polypeptide Antibody
  • MGC117044 Antibody
  • Mo1, alpha subunit Antibody
  • MO1A Antibody
  • Neutrophil adherence receptor Antibody
  • Neutrophil adherence receptor alpha M subunit Antibody
  • SLEB6 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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