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Anti-CD10 Antibody

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产品名称: Anti-CD10 Antibody
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简单介绍

Anti-CD10 Antibody


Anti-CD10 Antibody  的详细介绍
Name: Anti-CD10 Antibody
See all CD10 primary antibodies
Description: Rabbit polyclonal antibody to CD10
Applications: CM, ELISA, ICC, IF, IHC, IP, WB
Dilutions: ELISA: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:250; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 360-410 on human Neprilysin protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Concentration: 0.72-0.78 μg/μl in antibody stabilization buffer
Storage: -20?C for long term storage
Function: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Involvement in Disease: Charcot-Marie-Tooth disease 2T: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.

Spinocerebellar ataxia 43: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA43 is a slowly progressive, autosomal dominant form.
Sequence Similarities: Belongs to the peptidase M13 family.
Post-Translational Modification: Myristoylation is a determinant of membrane targeting.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 4311?Human
  • Entrez Gene: 17380?Mouse
  • Entrez Gene: 24590?Rat
  • Omim: 120520?Human
  • SwissProt: P08473?Human
  • SwissProt: Q61391?Mouse
  • SwissProt: P07861?Rat
  • Unigene: 307734?Human
  • Unigene: 296022?Mouse
  • Unigene: 33598?Rat
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    Synonyms:
  • Atriopeptidase Antibody
  • CALLA Antibody
  • CD10 Antibody
  • CD10 antigen Antibody
  • Common acute lymphocytic leukemia antigen Antibody
  • DKFZp686O16152 Antibody
  • EC 3.4.24.11 Antibody
  • Enkephalinase Antibody
  • EPN Antibody
  • Membrane metallo endopeptidase Antibody
  • Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) Antibody
  • Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) Antibody
  • Membrane metallo endopeptidase variant 1 Antibody
  • Membrane metallo endopeptidase variant 2 Antibody
  • Membrane metalloendopeptidase Antibody
  • Membrane metalloendopeptidase neutral endopeptidase enkephalinase Antibody
  • Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 Antibody
  • Membrane metalloendopeptidase variant 1 Antibody
  • Membrane metalloendopeptidase variant 2 Antibody
  • MGC126681 Antibody
  • MGC126707 Antibody
  • MME Antibody
  • NEP Antibody
  • Neprilysin Antibody
  • neprilysin-390 Antibody
  • neprilysin-411 Antibody
  • NEP_HUMAN Antibody
  • Neutral endopeptidase Antibody
  • Neutral endopeptidase 24.11 Antibody
  • Neutral endopeptidase, membrane-associated Antibody
  • SFE Antibody
  • Skin fibroblast elastase Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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