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Anti-CCR5 Antibody

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产品名称: Anti-CCR5 Antibody
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简单介绍

Anti-CCR5 Antibody


Anti-CCR5 Antibody  的详细介绍
Name: Anti-CCR5 Antibody
See all CCR5 primary antibodies
Description: Rabbit polyclonal antibody to CCR5
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Raised against a peptide corresponding to amino acids 6 to 20 of human CCR5.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: DEAE purified
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Tissue Specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Involvement in Disease: Diabetes mellitus, insulin-dependent, 22: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 1234?Human
  • Omim: 601373?Human
  • SwissProt: P51681?Human
  • Unigene: 450802?Human
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    Synonyms:
  • AM4 7 Antibody
  • C C chemokine receptor type 5 Antibody
  • C C CKR 5 Antibody
  • C-C chemokine receptor type 5 Antibody
  • C-C CKR-5 Antibody
  • C-C motif chemokine receptor 5 A159A Antibody
  • CC Chemokine Receptor 5 Antibody
  • CC Chemokine Receptor Type 5 Antibody
  • CC CKR 5 Antibody
  • CC-CKR-5 Antibody
  • CCCKR 5 Antibody
  • CCCKR5 Antibody
  • CCR 5 Antibody
  • CCR-5 Antibody
  • CCR5 Antibody
  • CCR5 chemokine (C C motif) receptor 5 Antibody
  • CCR5_HUMAN Antibody
  • CD 195 Antibody
  • CD195 Antibody
  • CD195 Antigen Antibody
  • Chemokine C C motif receptor 5 Antibody
  • Chemokine receptor CCR5 Antibody
  • CHEMR13 Antibody
  • CKR 5 Antibody
  • CKR5 Antibody
  • CMKBR 5 Antibody
  • CMKBR5 Antibody
  • FLJ78003 Antibody
  • HIV 1 Fusion Coreceptor Antibody
  • HIV-1 fusion coreceptor Antibody
  • HIV1 fusion coreceptor Antibody
  • IDDM22 Antibody
  • MIP-1 alpha receptor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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