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Anti-CCR4 Antibody

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产品名称: Anti-CCR4 Antibody
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Anti-CCR4 Antibody


Anti-CCR4 Antibody  的详细介绍
Name: Anti-CCR4 Antibody
See all CCR4 primary antibodies
Description: Rabbit polyclonal antibody to CCR4
Specificity: The antibody detects endogenous levels of total CCR4 protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide of human CCR4
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification
Concentration: 0.7mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Tissue Specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 1233?Human
  • GenBank: NP_005499.1?Human
  • Omim: 604836?Human
  • SwissProt: P51679?Human
  • Unigene: 184926?Human
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    Synonyms:
  • C C chemokine receptor type 4 Antibody
  • C C CKR 4 Antibody
  • C-C chemokine receptor type 4 Antibody
  • C-C CKR-4 Antibody
  • CC CKR 4 Antibody
  • CC-CKR-4 Antibody
  • CCR 4 Antibody
  • CCR-4 Antibody
  • CCR4 Antibody
  • CCR4_HUMAN Antibody
  • CD194 Antibody
  • Chemokine (CC motif) receptor 4 Antibody
  • chemokine C C motif receptor 4 Antibody
  • ChemR13 Antibody
  • CKR4 Antibody
  • CMKBR 4 Antibody
  • CMKBR4 Antibody
  • HGCN 14099 Antibody
  • K5 5 Antibody
  • K5-5 Antibody
  • MGC88293 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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