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Anti-CCNF Antibody

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产品名称: Anti-CCNF Antibody
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简单介绍

Anti-CCNF Antibody


Anti-CCNF Antibody  的详细介绍
Name: Anti-CCNF Antibody
See all CCNF primary antibodies
Description: Rabbit polyclonal antibody to CCNF
Specificity: The antibody detects endogenous levels of total CCNF protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human cyclin F
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Tissue Specificity: Widely expressed.
Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.
Post-Translational Modification: Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
Cellular Location: Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole.

Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
Database Links:
  • Entrez Gene: 899?Human
  • Omim: 600227?Human
  • SwissProt: P41002?Human
  • Unigene: 1973?Human
    		•
    Synonyms:
  • Ccnf Antibody
  • CCNF_HUMAN Antibody
  • Cyclin F Antibody
  • Cyclin-F Antibody
  • F box only protein 1 Antibody
  • F-box only protein 1 Antibody
  • FBX1 Antibody
  • FBXO1 Antibody
  • G2 mitotic specific cyclin F Antibody
  • G2/mitotic specific cyclin F Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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