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Anti-CCND3 Antibody

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产品名称: Anti-CCND3 Antibody
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Anti-CCND3 Antibody


Anti-CCND3 Antibody  的详细介绍
Name: Anti-CCND3 Antibody
See all CCND3 primary antibodies
Description: Rabbit polyclonal antibody to CCND3
Specificity: The antibody detects endogenous levels of total CCND3 protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human cyclin D3
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.8mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Sequence Similarities: Belongs to the cyclin family. Cyclin D subfamily.
Post-Translational Modification: Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Cellular Location: Nucleus. Cytoplasm. Membrane.

Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
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