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Anti-CCND2 Antibody

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产品名称: Anti-CCND2 Antibody
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Anti-CCND2 Antibody


Anti-CCND2 Antibody  的详细介绍
Name: Anti-CCND2 Antibody
See all CCND2 primary antibodies
Description: Rabbit polyclonal antibody to CCND2
Specificity: The antibody detects endogenous level of total CCND2 antibody.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant Protein of human CCND2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Involvement in Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
Sequence Similarities: Belongs to the cyclin family. Cyclin D subfamily.
Post-Translational Modification: Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Cellular Location: Nucleus. Cytoplasm. Membrane.

Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Database Links:
  • Entrez Gene: 894 Human
  • Entrez Gene: 12444 Mouse
  • Entrez Gene: 64033 Rat
  • Omim: 123833 Human
  • SwissProt: P30279 Human
  • SwissProt: P30280 Mouse
  • SwissProt: Q04827 Rat
  • Unigene: 376071 Human
  • Unigene: 333406 Mouse
  • Unigene: 96083 Rat
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    Synonyms:
  • CCND 2 Antibody
  • ccnd2 Antibody
  • CCND2_HUMAN Antibody
  • Cyclin D2 Antibody
  • CyclinD2 Antibody
  • G1/S specific cyclin D2 Antibody
  • G1/S-specific cyclin-D2 Antibody
  • KIAK0002 Antibody
  • MGC102758 Antibody
  • MPPH3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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