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Anti-CCNC Antibody

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产品名称: Anti-CCNC Antibody
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简单介绍

Anti-CCNC Antibody


Anti-CCNC Antibody  的详细介绍
Name: Anti-CCNC Antibody
See all CCNC primary antibodies
Description: Rabbit polyclonal antibody to CCNC
Specificity: CCNC polyclonal antibody detects endogenous levels of CCNC protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CCNC.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 33 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Tissue Specificity: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Sequence Similarities: Belongs to the cyclin family. Cyclin C subfamily.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 892?Human
  • Entrez Gene: 51813?Mouse
  • Entrez Gene: 114839?Rat
  • Omim: 123838?Human
  • SwissProt: P24863?Human
  • SwissProt: Q62447?Mouse
  • SwissProt: P39947?Rat
  • Unigene: 430646?Human
  • Unigene: 633351?Human
  • Unigene: 278584?Mouse
  • Unigene: 106758?Rat
    		•
    Synonyms:
  • ccnc Antibody
  • CCNC_HUMAN Antibody
  • CycC Antibody
  • Cyclin C Antibody
  • Cyclin-C Antibody
  • hSRB11 Antibody
  • OTTHUMP00000016897 Antibody
  • SRB11 homolog Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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