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Anti-CCKBR Antibody

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产品名称: Anti-CCKBR Antibody
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Anti-CCKBR Antibody


Anti-CCKBR Antibody  的详细介绍
Name: Anti-CCKBR Antibody
See all CCKBR primary antibodies
Description: Rabbit polyclonal antibody to CCKBR
Specificity: The antibody detects endogenous level of total CCKBR protein.
Applications: E, WB, IHC
Dilutions: ELISA: 1:1000-1:5000 Western blotting: 1:2000-1:5000 Immunohistochemistry: 1:50-1:150
Reactivity: Human
Immunogen: Synthetic peptide corresponding to a region derived from 39-53 amino acids of Human cholecystokinin B receptor
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Predicted MW: 49kd
Formulation: Supplied at 3.2mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Tissue Specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 887?Human
  • Omim: 118445?Human
  • SwissProt: P32239?Human
  • Unigene: 203?Human
    		•
    Synonyms:
  • CCK B Antibody
  • CCK B receptor Antibody
  • CCK BR Antibody
  • CCK-B receptor Antibody
  • CCK-BR Antibody
  • CCK2 R Antibody
  • CCK2 receptor Antibody
  • CCK2-R Antibody
  • CCKB Antibody
  • CCKB receptor Antibody
  • CCKBR Antibody
  • CCKR Type B Antibody
  • CCKRB Antibody
  • Cholecystokinin 2 receptor Antibody
  • Cholecystokinin B receptor Antibody
  • Cholecystokinin-2 receptor Antibody
  • Cholecystokinin2 receptor Antibody
  • CholecystokininB receptor Antibody
  • GASR Antibody
  • GASR_HUMAN Antibody
  • Gastrin receptor Antibody
  • Gastrin/cholecystokinin type B receptor Antibody
  • Gastrincholecystokinin brain receptor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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