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Anti-CCDC98 Antibody

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产品名称: Anti-CCDC98 Antibody
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Anti-CCDC98 Antibody


Anti-CCDC98 Antibody  的详细介绍
Name: Anti-CCDC98 Antibody
See all CCDC98 primary antibodies
Description: Rabbit polyclonal antibody to CCDC98
Applications: E, WB, IHC
Reactivity: Human, Mouse
Immunogen: Raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Sequence Similarities: Belongs to the FAM175 family. Abraxas subfamily.
Post-Translational Modification: Phosphorylation of Ser-404 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.
Cellular Location: Nucleus.

Localizes at sites of DNA damage at double-strand breaks (DSBs).
Database Links:
  • Entrez Gene: 84142?Human
  • Entrez Gene: 70681?Mouse
  • Omim: 611143?Human
  • SwissProt: Q6UWZ7?Human
  • SwissProt: Q8BPZ8?Mouse
  • Unigene: 334772?Human
  • Unigene: 221269?Mouse
    		•
    Synonyms:
  • 3830405G04Rik Antibody
  • 5630400M01Rik Antibody
  • ABRA1 Antibody
  • ABRAXAS Antibody
  • Abraxas protein Antibody
  • AI506069 Antibody
  • AL024423 Antibody
  • AV118690 Antibody
  • BRCA1-A complex subunit Abraxas Antibody
  • CCDC98 Antibody
  • coiled coil domain containing 98 Antibody
  • Coiled-coil domain-containing protein 98 Antibody
  • F175A_HUMAN Antibody
  • FAM175A Antibody
  • Family with sequence similarity 175 member A Antibody
  • FLJ11520 Antibody
  • FLJ12642 Antibody
  • FLJ13614 Antibody
  • Protein FAM175A Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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