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Anti-CCDC88A Antibody

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产品名称: Anti-CCDC88A Antibody
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简单介绍

Anti-CCDC88A Antibody


Anti-CCDC88A Antibody  的详细介绍
Name: Anti-CCDC88A Antibody
See all CCDC88A primary antibodies
Description: Rabbit polyclonal antibody to CCDC88A
Specificity: The antibody detects endogenous levels of total CCDC88A protein.
Applications: IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human coiled-coil domain containing 88A
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.7mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during ***** neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382).
Tissue Specificity: Expressed ubiquitously.
Involvement in Disease: PEHO syndrome: An autosomal recessive syndrome characterized by progressive encephalopathy, lack of psychomotor development, severe mental retardation, early onset epileptic seizures, optic nerve/cerebellar atrophy, pedal edema, and early death.
Sequence Similarities: Belongs to the CCDC88 family.
Post-Translational Modification: Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.
Cellular Location: Membrane. Cell membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle. Cell projection > Lamellipodium. Cytoplasm > Cytoskeleton > Cilium basal body. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole.

Localizes to the cell membrane through interaction with phosphoinositides.
Database Links:
  • Entrez Gene: 55704?Human
  • Entrez Gene: 108686?Mouse
  • Omim: 609736?Human
  • SwissProt: Q3V6T2?Human
  • SwissProt: Q5SNZ0?Mouse
  • Unigene: 292925?Human
  • Unigene: 338284?Mouse
  • Unigene: 441367?Mouse
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    Synonyms:
  • AKT iphosphorylation enhancer Antibody
  • Akt phosphorylation enhancer Antibody
  • APE Antibody
  • Ccdc88a Antibody
  • Coiled coil domain containing 88A Antibody
  • Coiled coil domain containing protein 88A Antibody
  • Coiled-coil domain-containing protein 88A Antibody
  • FLJ10392 Antibody
  • G alpha interacting vesicle associated protein Antibody
  • G alpha-interacting vesicle-associated protein Antibody
  • Galpha interacting vesicle associated protein Antibody
  • Girders of actin filament Antibody
  • Girdin Antibody
  • GIV Antibody
  • GRDN Antibody
  • GRDN_HUMAN Antibody
  • HkRP1 Antibody
  • Hook related protein 1 Antibody
  • Hook-related protein 1 Antibody
  • KIAA1212 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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