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Anti-CBX3 Antibody

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产品名称: Anti-CBX3 Antibody
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Anti-CBX3 Antibody


Anti-CBX3 Antibody  的详细介绍
Name: Anti-CBX3 Antibody
See all CBX3 primary antibodies
Description: Rabbit polyclonal antibody to CBX3
Specificity: The antibody detects endogenous levels of total CBX3 protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to residues near the N terminal of human chromobox homolog 3
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.4mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Post-Translational Modification: Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Cellular Location: Nucleus.

Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
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