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Anti-CBLB Antibody

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产品名称: Anti-CBLB Antibody
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简单介绍

Anti-CBLB Antibody


Anti-CBLB Antibody  的详细介绍
Name: Anti-CBLB Antibody
See all CBLB primary antibodies
Description: Rabbit polyclonal antibody to CBLB
Specificity: CBLB pAb detects endogenous levels of CBLB protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CBLB.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 109 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Tissue Specificity: Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in ***** brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level).
Post-Translational Modification: Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.
Cellular Location: Cytoplasm.

Upon EGF stimulation, associates with endocytic vesicles.
Database Links:
  • Entrez Gene: 868?Human
  • Entrez Gene: 208650?Mouse
  • Entrez Gene: 171136?Rat
  • Omim: 604491?Human
  • SwissProt: Q13191?Human
  • SwissProt: Q3TTA7?Mouse
  • SwissProt: Q8K4S7?Rat
  • Unigene: 430589?Human
  • Unigene: 328206?Mouse
  • Unigene: 21799?Rat
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    Synonyms:
  • AI429560 Antibody
  • AI851073 Antibody
  • Cas Br M (murine) ecotropic retroviral transforming sequence b Antibody
  • Casitas B lineage lymphoma b Antibody
  • Casitas B lineage lymphoma proto oncogene b Antibody
  • Casitas B-lineage lymphoma proto-oncogene b Antibody
  • Cbl b Antibody
  • CBLB Antibody
  • CBLB_HUMAN Antibody
  • DKFZp686J10223 Antibody
  • DKFZp779A0729 Antibody
  • DKFZp779F1443 Antibody
  • E3 ubiquitin protein ligase CBL B Antibody
  • E3 ubiquitin-protein ligase CBL-B Antibody
  • EC 6.3.2.- Antibody
  • FLJ36865 Antibody
  • FLJ41152 Antibody
  • Nbla00127 Antibody
  • RING finger protein 56 Antibody
  • RNF56 Antibody
  • SH3 binding protein CBL B Antibody
  • SH3-binding protein CBL-B Antibody
  • Signal transduction protein CBL B Antibody
  • Signal transduction protein CBL-B Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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