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Anti-Cbl Antibody

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产品名称: Anti-Cbl Antibody
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简单介绍

Anti-Cbl Antibody


Anti-Cbl Antibody  的详细介绍
Name: Anti-Cbl Antibody
See all Cbl primary antibodies
Description: Rabbit polyclonal antibody to Cbl
Applications: E, WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 14 amino acid peptide from near the carboxy terminus of human cbl.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Post-Translational Modification: Phosphorylated on tyrosine residues by ALK, EGFR, FGR, INSR, SYK, FYN and ZAP70. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Phosphorylated on tyrosine residues by activated PDGFRA and PDGFRB (By similarity). Phosphorylated on tyrosine residues in response to CSF1R, FLT1 and KIT signaling. Phosphorylated on tyrosine residues by HCK.
Cellular Location: Cytoplasm. Cell membrane.

Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Database Links:
  • Entrez Gene: 867 Human
  • Entrez Gene: 12402 Mouse
  • Entrez Gene: 500985 Rat
  • Omim: 165360 Human
  • SwissProt: P22681 Human
  • SwissProt: P22682 Mouse
  • Unigene: 504096 Human
  • Unigene: 266871 Mouse
    		•
    Synonyms:
  • 4732447J05Rik Antibody
  • C CBL Antibody
  • Cas Br M (murine) ecotropic retroviral transforming sequence Antibody
  • Casitas B lineage lymphoma proto oncogene Antibody
  • Casitas B-lineage lymphoma proto-oncogene Antibody
  • CBL Antibody
  • CBL 2 Antibody
  • CBL2 Antibody
  • CBL_HUMAN Antibody
  • E3 ubiquitin protein ligase CBL Antibody
  • E3 ubiquitin-protein ligase CBL Antibody
  • Oncogene CBL2 Antibody
  • Proto oncogene c CBL Antibody
  • Proto-oncogene c-CBL Antibody
  • RGD1561386 Antibody
  • RING finger protein 55 Antibody
  • RNF55 Antibody
  • Signal transduction protein CBL Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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