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Anti-CBFA2T2 Antibody

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产品名称: Anti-CBFA2T2 Antibody
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Anti-CBFA2T2 Antibody


Anti-CBFA2T2 Antibody  的详细介绍
Name: Anti-CBFA2T2 Antibody
See all CBFA2T2 primary antibodies
Description: Rabbit polyclonal antibody to CBFA2T2
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 401 and 598 of human CBFA2T2
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity).
Tissue Specificity: Ubiquitously expressed in fetal and ***** tissues. Highly expressed in ***** brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
Sequence Similarities: Belongs to the CBFA2T family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 9139 Human
  • Omim: 601308 Human
  • Omim: 603672 Human
  • SwissProt: O43439 Human
  • Unigene: 153934 Human
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    Synonyms:
  • AML1 MTG8 Antibody
  • cbfa2t2 Antibody
  • Core binding factor runt domain alpha subunit 2 translocated to 2 Antibody
  • core-binding factor, runt domain, alpha subunit 2 Antibody
  • DKFZp313F2116 Antibody
  • EHT Antibody
  • ETO homolog on chromosome 20 Antibody
  • ETO homologous on chromosome 20 Antibody
  • MTG 8 like protein Antibody
  • MTG 8 related protein 1 Antibody
  • MTG8 like protein Antibody
  • MTG8 related protein 1 Antibody
  • MTG8-like protein Antibody
  • MTG8-related protein 1 Antibody
  • MTG8R_HUMAN Antibody
  • MTGR 1 Antibody
  • MTGR1 Antibody
  • Myeloid translocation gene related protein 1 Antibody
  • Myeloid translocation related protein 1 Antibody
  • Myeloid translocation-related protein 1 Antibody
  • p85 Antibody
  • Protein CBFA2T2 Antibody
  • ZMYND 3 Antibody
  • ZMYND3 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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