产品资料

Anti-CBFA1 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-CBFA1 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-CBFA1 Antibody


Anti-CBFA1 Antibody  的详细介绍
Name: Anti-CBFA1 Antibody
See all CBFA1 primary antibodies
Description: Rabbit polyclonal antibody to CBFA1
Specificity: The antibody detects endogenous level of total CBFA1 protein.
Applications: E, WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region derived from 320-336 amino acids of Human Core-binding factor subunit alpha-1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Formulation: Supplied at 0.8mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Tissue Specificity: Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T-cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines.
Post-Translational Modification: Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression (By similarity).
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 860?Human
  • Entrez Gene: 12393?Mouse
  • Omim: 600211?Human
  • SwissProt: Q13950?Human
  • SwissProt: Q08775?Mouse
  • Unigene: 535845?Human
  • Unigene: 391013?Mouse
  • Unigene: 391017?Mouse
    		•
    Synonyms:
  • Acute myeloid leukemia 3 protein Antibody
  • Alpha subunit 1 Antibody
  • AML3 Antibody
  • CBF alpha 1 Antibody
  • CBF-alpha-1 Antibody
  • CBFA1 Antibody
  • CCD Antibody
  • CCD1 Antibody
  • Cleidocranial dysplasia 1 Antibody
  • Core binding factor Antibody
  • Core binding factor runt domain alpha subunit 1 Antibody
  • Core binding factor subunit alpha 1 Antibody
  • Core-binding factor subunit alpha-1 Antibody
  • MGC120022 Antibody
  • MGC120023 Antibody
  • Oncogene AML 3 Antibody
  • Oncogene AML-3 Antibody
  • OSF 2 Antibody
  • OSF-2 Antibody
  • OSF2 Antibody
  • Osteoblast specific transcription factor 2 Antibody
  • Osteoblast-specific transcription factor 2 Antibody
  • OTTHUMP00000016533 Antibody
  • PEA2 alpha A Antibody
  • PEA2-alpha A Antibody
  • PEA2aA Antibody
  • PEBP2 alpha A Antibody
  • PEBP2-alpha A Antibody
  • PEBP2A1 Antibody
  • PEBP2A2 Antibody
  • PEBP2aA Antibody
  • PEBP2aA1 Antibody
  • Polyomavirus enhancer binding protein 2 alpha A subunit Antibody
  • Polyomavirus enhancer-binding protein 2 alpha A subunit Antibody
  • Runt domain Antibody
  • Runt related transcription factor 2 Antibody
  • Runt-related transcription factor 2 Antibody
  • RUNX2 Antibody
  • RUNX2_HUMAN Antibody
  • SL3 3 enhancer factor 1 alpha A subunit Antibody
  • SL3-3 enhancer factor 1 alpha A subunit Antibody
  • SL3/AKV core binding factor alpha A subunit Antibody
  • SL3/AKV core-binding factor alpha A subunit Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号