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Anti-Cathepsin E (I292) Antibody

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产品名称: Anti-Cathepsin E (I292) Antibody
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Anti-Cathepsin E (I292) Antibody


Anti-Cathepsin E (I292) Antibody  的详细介绍
Name: Anti-Cathepsin E (I292) Antibody
See all Cathepsin E primary antibodies
Description: Rabbit polyclonal antibody to Cathepsin E (I292)
Specificity: Cathepsin?E (I292) pAb detects endogenous levels of Cathepsin?E protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 260-310 of Human Cathepsin E.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 48 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Tissue Specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
Sequence Similarities: Belongs to the peptidase A1 family.
Post-Translational Modification: Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Cellular Location: Endosome.

The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Database Links:
  • Entrez Gene: 1510?Human
  • Entrez Gene: 13034?Mouse
  • Entrez Gene: 25424?Rat
  • Omim: 116890?Human
  • SwissProt: P14091?Human
  • SwissProt: P70269?Mouse
  • SwissProt: P16228?Rat
  • Unigene: 644082?Human
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    Synonyms:
  • CATE Antibody
  • CATE_HUMAN Antibody
  • Cathepsin E Antibody
  • Cathepsin E form II Antibody
  • CTSE Antibody
  • Erythrocyte membrane aspartic proteinase Antibody
  • Slow moving proteinase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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