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Anti-Catenin-δ1 Antibody

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产品名称: Anti-Catenin-δ1 Antibody
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Anti-Catenin-δ1 Antibody


Anti-Catenin-δ1 Antibody  的详细介绍
Name: Anti-Catenin-δ1 Antibody
See all Catenin-δ1 primary antibodies
Description: Rabbit polyclonal antibody to Catenin-δ1
Specificity: Catenin-δ1 pAb detects endogenous levels of Catenin-δ1 protein.
Applications: WB, IHC, ICC, IF, IP
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Catenin-δ1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 108 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Tissue Specificity: Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
Sequence Similarities: Belongs to the beta-catenin family.
Post-Translational Modification: Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.
Cellular Location: Cytoplasm. Nucleus. Cell membrane.

Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus.
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