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Anti-Catenin-γ Antibody

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产品名称: Anti-Catenin-γ Antibody
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Anti-Catenin-γ Antibody


Anti-Catenin-γ Antibody  的详细介绍
Name: Anti-Catenin-γ Antibody
See all Catenin-γ primary antibodies
Description: Rabbit polyclonal antibody to Catenin-γ
Specificity: Catenin-γ Polyclonal Antibody detects endogenous levels of Catenin-γ protein.
Applications: WB, IHC, IF, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the C-terminal region of human Catenin-γ.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Involvement in Disease: Naxos disease: An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.

Arrhythmogenic right ventricular dysplasia, familial, 12: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Sequence Similarities: Belongs to the beta-catenin family.
Post-Translational Modification: May be phosphorylated by FER.
Cellular Location: Cell junction > Adherens junction. Cell junction > Desmosome. Cytoplasm > Cytoskeleton. Membrane.

Cytoplasmic in a soluble and membrane-associated form.
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