产品资料

Anti-Caspase-14 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-Caspase-14 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-Caspase-14 Antibody


Anti-Caspase-14 Antibody  的详细介绍
Name: Anti-Caspase-14 Antibody
See all Caspase-14 primary antibodies
Description: Rabbit polyclonal antibody to Caspase-14
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 16 amino acid peptide from near the carboxy terminus of human caspase-14.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification (PubMed:18156206). Regulates maturation of the epidermis by proteolytically processing filaggrin (PubMed:21654840). In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis (PubMed:24872419). May be involved in retinal pigment epithelium cell barrier function (By similarity).
Tissue Specificity: Embryo, ***** liver and less in ***** brain and kidney. Expressed in differentiating keratinocytes of embryonic skin (at protein level). Expressed in keratinocytes of ***** skin suprabasal layers (at protein level).
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts the precursor to yield the p17/p10 mature form (By similarity). Initially it was reported that cleavage by granzyme B, caspase-8 and -10 generates the two active subunits, however the physiological relevance has not been established (PubMed:9823333).
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 23581?Human
  • Entrez Gene: 12365?Mouse
  • Entrez Gene: 299587?Rat
  • Omim: 605848?Human
  • SwissProt: P31944?Human
  • SwissProt: O89094?Mouse
  • Unigene: 466057?Human
  • Unigene: 20940?Mouse
  • Unigene: 228179?Rat
    		•
    Synonyms:
  • Apoptosis related cysteine protease Antibody
  • CASP 14 Antibody
  • CASP-14 Antibody
  • CASP14 Antibody
  • Caspase 14 apoptosis related cysteine protease Antibody
  • Caspase 14 precursor Antibody
  • Caspase-14 Antibody
  • Caspase-14 subunit p10 Antibody
  • Caspase14 Antibody
  • CASPE_HUMAN Antibody
  • MGC119078 Antibody
  • MGC119079 Antibody
  • MICE Antibody
  • Mini ICE Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号