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Anti-Caspase-1 p20 (D210) Antibody

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产品名称: Anti-Caspase-1 p20 (D210) Antibody
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Anti-Caspase-1 p20 (D210) Antibody


Anti-Caspase-1 p20 (D210) Antibody  的详细介绍
Name: Anti-Caspase-1 p20 (D210) Antibody
See all Caspase-1 p20 primary antibodies
Description: Rabbit polyclonal antibody to Caspase-1 p20 (D210)
Specificity: Caspase-1 p20 (D210) pAb detects endogenous levels of pro-caspase-1 and the caspase-1 p20 subunit. The antibody is expected to detect alpha, beta, gamma and delta isoforms.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human Caspase-1 p20.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 20, 30-45, 50 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Tissue Specificity: Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cellular Location: Cytoplasm.
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