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Anti-Caspase 9 (Phospho-Thr125) Antibody

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产品名称: Anti-Caspase 9 (Phospho-Thr125) Antibody
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Anti-Caspase 9 (Phospho-Thr125) Antibody


Anti-Caspase 9 (Phospho-Thr125) Antibody  的详细介绍
Name: Anti-Caspase 9 (Phospho-Thr125) Antibody
See all Caspase 9 primary antibodies
Description: Rabbit polyclonal antibody to Caspase 9 (Phospho-Thr125)
Specificity: The antiserum was produced against synthesized phosphopeptide derived from human Caspase 9 around the phosphorylation site of threonine 125 (P-E-TP-P-R).
Applications: WB, IHC
Dilutions: Western blotting: 1:500~1:1000Immunohistochemistry: 1:50~1:100
Reactivity: Human
Immunogen: Peptide sequence around phosphorylation site of threonine 125 (P-E-T(p)-P-R) derived from Human Caspase 9.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Synonyms:
  • APAF3 Antibody
  • CASP9 Antibody
  • Caspase 9 Antibody
  • ICE LAP6 Antibody
  • MCH6 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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