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Anti-Caspase 7 p11 Antibody

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产品名称: Anti-Caspase 7 p11 Antibody
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Anti-Caspase 7 p11 Antibody


Anti-Caspase 7 p11 Antibody  的详细介绍
Name: Anti-Caspase 7 p11 Antibody
See all Caspase 7 p11 primary antibodies
Description: Rabbit polyclonal antibody to Caspase 7 p11
Specificity: Caspase 7 p11 pAb recognizes endogenous levels of total caspase-7 protein and the p11 subunit of mature caspase-7.
Applications: WB, ICC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 217-262 of Human Caspase 7.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 11, 34 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Tissue Specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
Cellular Location: Cytoplasm.
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