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Anti-Caspase 7 Antibody

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产品名称: Anti-Caspase 7 Antibody
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简单介绍

Anti-Caspase 7 Antibody


Anti-Caspase 7 Antibody  的详细介绍
Name: Anti-Caspase 7 Antibody
See all Caspase 7 primary antibodies
Description: Rabbit polyclonal antibody to Caspase 7
Specificity: Caspase 7 pAb detects endogenous levels of Caspase 7 protein.
Applications: WB, IHC, ICC, IP
Reactivity: Human, Mouse
Immunogen: Recombinant full length Human Caspase 7.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 34 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Tissue Specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 840?Human
  • Entrez Gene: 12369?Mouse
  • Omim: 601761?Human
  • SwissProt: P55210?Human
  • SwissProt: P97864?Mouse
  • Unigene: 9216?Human
  • Unigene: 35687?Mouse
    		•
    Synonyms:
  • Apoptotic protease Mch-3 Antibody
  • Apoptotic protease MCH3 Antibody
  • CASP-7 Antibody
  • CASP7 Antibody
  • CASP7_HUMAN Antibody
  • Caspase 7 Antibody
  • Caspase 7 apoptosis related cysteine peptidase Antibody
  • Caspase-7 Antibody
  • Caspase-7 subunit p11 Antibody
  • Caspase7 Antibody
  • CMH 1 Antibody
  • CMH-1 Antibody
  • CMH1 Antibody
  • ICE LAP3 Antibody
  • ICE-LAP3 Antibody
  • ICE-like apoptotic protease 3 Antibody
  • LICE2 Antibody
  • MCH3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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