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Anti-Caspase 14 Antibody

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产品名称: Anti-Caspase 14 Antibody
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Anti-Caspase 14 Antibody


Anti-Caspase 14 Antibody  的详细介绍
Name: Anti-Caspase 14 Antibody
See all Caspase14 primary antibodies
Description: Rabbit polyclonal antibody to Caspase 14
Applications: WB, IF
Dilutions: Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 171 and 230 of Caspase 14
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Predicted MW: 28kd
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Tissue Specificity: Expressed in keratinocytes of ***** skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form (PubMed:22825846). Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme (PubMed:12200134).
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 23581 Human
  • Omim: 605848 Human
  • SwissProt: P31944 Human
  • Unigene: 466057 Human
    		•
    Synonyms:
  • Apoptosis related cysteine protease Antibody
  • CASP 14 Antibody
  • CASP-14 Antibody
  • CASP14 Antibody
  • Caspase 14 apoptosis related cysteine protease Antibody
  • Caspase 14 precursor Antibody
  • Caspase-14 Antibody
  • Caspase-14 subunit p10 Antibody
  • Caspase14 Antibody
  • CASPE_HUMAN Antibody
  • MGC119078 Antibody
  • MGC119079 Antibody
  • MICE Antibody
  • Mini ICE Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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