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Anti-Caspase 10 (K442) Antibody

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产品名称: Anti-Caspase 10 (K442) Antibody
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Anti-Caspase 10 (K442) Antibody


Anti-Caspase 10 (K442) Antibody  的详细介绍
Name: Anti-Caspase 10 (K442) Antibody
See all Caspase 10 primary antibodies
Description: Rabbit polyclonal antibody to Caspase 10 (K442)
Specificity: Caspase 10 (K442) pAb detects endogenous levels of Caspase 10 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 410-462 of Human Caspase 10.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 59 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
Tissue Specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Involvement in Disease: Autoimmune lymphoproliferative syndrome 2A: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.

Familial non-Hodgkin lymphoma: Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.

Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Database Links:
  • Entrez Gene: 843?Human
  • Omim: 601762?Human
  • SwissProt: Q92851?Human
  • Unigene: 5353?Human
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    Synonyms:
  • ALPS2 Antibody
  • Apoptotic protease MCH 4 Antibody
  • CASP 10 Antibody
  • Caspase 10 Antibody
  • Fas associated death domain protein Antibody
  • FLICE 2 Antibody
  • ICE like apoptotic protease 4 Antibody
  • MCH 4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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