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Anti-CASP9 Antibody

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产品名称: Anti-CASP9 Antibody
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Anti-CASP9 Antibody


Anti-CASP9 Antibody  的详细介绍
Name: Anti-CASP9 Antibody
See all CASP9 primary antibodies
Description: Rabbit polyclonal antibody to CASP9
Specificity: The antibody detects endogenous level of total CASP9 antibody.
Applications: WB, IF
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human CASP9.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
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